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PubMed A Novel Coronavirus from Patients with Pneumonia in China, 2019. Zhu N1, Zhang D1, Wang W1, Li X1, Yang B1, Song J1, Zhao X1, Huang B1, Shi W1, Lu R1, Niu P1, Zhan F1, Ma X1, Wang D1, Xu W1, Wu G1, Gao GF1, Tan W1; China Abstract In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown beta-coronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel corona-virus, named 2019-nCoV, which formed another clade within the sub-genus sarbe-covirus,…
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Homologous recombination within the spike glyco-protein of the newly identified corona-virus may boost cross-species transmission from snake to human.
Journal: Journal of medical virology January/22/2020 The current outbreak of viral pneumonia in the city of Wuhan, China, was caused by a novel corona-virus designated 2019-nCoV by the World Health Organization, as determined by sequencing the viral RNA genome. Many patients were potentially exposed to wildlife animals at the Huanan seafood wholesale market, where poultry, snake, bats, and other farm animals were also sold. To determine the possible virus reservoir, we have carried out comprehensive sequence analysis and comparison in conjunction with relative synonymous codon usage (RSCU) bias among different animal species based on existing sequences of the newly identified coronavirus 2019-nCoV. Results obtained from our analyses suggest that the…
Laboratory Research Protocols
