This article is contributed by the COBRE for Reproductive Health. The programmatic and scientific goals of this COBRE support a multidisciplinary, translational, and innovative program in women’s reproductive health. The research projects focus on using pre-clinical and human models to understand mechanisms of preeclampsia, gestational diabetes, preterm birth, IVF pregnancies, and the application of contemporary computational approaches to identify the networks and pathways underlying these devastating pregnancy complications. We discuss how novel observations emanating from the preeclampsia project can be leveraged to understand chronic diseases such as Alzheimer’s disease (AD). Proteinopathy is a hallmark feature of neurodegenerative disorders such as AD. We recently reported that preeclampsia (PE), a severe pregnancy…