Additive manufacturing methods (i.e., 3D printing) are quickly turning into one of the preferred strategies for the preparation of supplies to be employed in many various fields, together with biomedical functions. The essential motive is the distinctive flexibility ensuing from each the strategy itself and the variability of beginning supplies, requiring the mix of multidisciplinary competencies for the optimization of the method. In specific, that is the case of additive manufacturing processes primarily based on the extrusion or jetting of nanocomposite supplies, the place the distinctive properties of nanomaterials are mixed with these of a flowing matrix. This contribution focuses on the physico-chemical challenges sometimes confronted in the 3D printing…